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Artren generico di S. Lello (G. D'Erven).
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Amlodipine besylate and weight loss results are modest but consistent with many clinical trials of drug treatment obese and overweight patients. Adverse effects are common, including gastrointestinal, pulmonary, gynecologic, and cardiac effects. It is contraindicated in patients with active pancreatitis, malignant neoplasms, or kidney and hepatic impairment, as well in those receiving anticoagulation or antidiabetic drug therapy. For patients with impaired renal function, there have been reports of serious hepatotoxicity in association with this agent. Pregnancy and lactation: Animal reproduction studies have not been conducted with this drug. Pregnancy Category WARNING The US National Library of Medicine has classified this drug as a Schedule 3-IV drug, with abuse potential and dependence potential. Reproductive Effects: Pregnancy Category WARNING The US National Library of Medicine has classified this drug as a Schedule 3 drug, with abuse potential and dependence potential. Reproductive Effects: In animal reproduction tests, an estimated incidence of 8.8% to 16.7% occurs in dams receiving chronic treatment. Fetal/ neonatal toxicity has been reported with repeated administration and dose escalation after the first dose. In infants and children, acute toxicity studies in rats exposed to a single dose of 1% and an estimated human exposure from 15% to 30% of the dose received during first month of life occurred; both doses produced a dose-related increase in the incidence of seizures, ataxia, hyporeflexia, and slurring of speech. The incidence these effects in human subjects was similar to the equivalent dose. Based on available information, there are no adequate and well-controlled studies in pregnant women. The drug is contraindicated during pregnancy and should be used during pregnancy only if clearly needed and under the close supervision of a physician. Breast-feeding: No data. Neonatal Effects: Neonates are generally